Guadalupe On Main is a standout restaurant in Mesa, AZ, where exceptional food, welcoming service, and a vibrant atmosphere come together to create a memorable dining experience.
Located at 1526 E Main St, this highly rated destination has earned a strong reputation with customers, holding an impressive 4.70 out of 5 rating based on 817 reviews. Guests return for the consistently enjoyable experience, whether they are stopping in for brunch, lunch, dinner, or dessert.
With a menu that features comfort food, healthy options, small plates, local specialties, coffee, beer, cocktails, and happy-hour drinks, Guadalupe On Main offers something for every appetite and occasion.
The restaurant is designed to make dining easy, enjoyable, and inclusive, with a range of convenient service options including on-site service, takeaway, dine-in, and delivery.
Its highlights reflect the energy and quality that keep people coming back: fast service, a great beer selection, great cocktails, great dessert, and live music all contribute to an atmosphere that feels both lively and inviting.
Whether you are dining solo, meeting friends for lunch, planning a romantic evening, or gathering for a relaxed dinner, the setting adapts beautifully to the moment. The restaurant is known for its casual yet cozy feel, while also offering a trendy and upmarket touch that makes it suitable for both everyday meals and special occasions.
Guadalupe On Main also places a strong emphasis on accessibility and guest comfort. Wheelchair-accessible parking, entrance, seating, and restrooms help ensure that more people can enjoy the restaurant with ease and confidence. Additional thoughtful details such as table service, a bar on site, and restroom facilities add to the overall convenience.
Reservations are accepted, and dinner reservations are recommended, making it easy for guests to plan ahead and enjoy a smooth experience. With flexible payment options including credit cards, debit cards, and NFC mobile payments, every part of the visit is designed to be straightforward and stress-free.
For those seeking a restaurant that combines quality, atmosphere, accessibility, and dependable service, Guadalupe On Main delivers an experience that feels warm, polished, and truly worth returning to.
Popular Items
Frequently ordered and highly recommended items at Guadalupe On Main
Our Story
Welcome to a place where great food meets warm hospitality. We believe dining is more than just a meal - it's an experience to be savored and shared.
Our kitchen is dedicated to creating dishes that bring people together, using recipes that honor tradition while embracing innovation.
Photos
A glimpse of our restaurant experience
Food & Drinks
Hear from our valued guests
My family and I went to this restaurant not knowing what to expect as we had never been there before and we're blown away. The atmosphere was upbeat and the wait staff were all very nice a ND attentive. The food was fantastic! The molé was amazing! The flavor deep and rich, corn tortillas thick and authentic as were the rice and even the beans! Delicious food! Hats off to the chef! The price was not what we expected. It was very affordable especially for the quality and quantity of the meal. My sister even tipped the kitchen and met the owner who was very personable and came to our table to talk with us. We just found our favorite place to go for very authentic Mexican food. Bravo 👏🏼 we will be back!
It's not every day you get to talk to the owner of the restaurant. We had a delicious lunch. We're visiting from California. Gluten-free options. Clean restrooms, friendly staff, accommodating to please you. My friend ordered a alcohol drink that was too strong for her, so the bar tender was okay with making a new one. What a surprise. She thought they were just going to add ice to water it down some. Nope, a whole new drink. So sweet of them. Great customer service. You won't be disappointed. Opens at 11 am. Enjoy!
They bring the hospitality back to the industry! Everybody is so friendly and we love to belly up to the bar for this reason. Almost everything on the menu is gluten-free which is great for my wife. The food is absolutely amazing, and the specialty cocktails are original and great. We have been there four times and introduced eight of our friends to the place. Everybody absolutely loves it. Try the shrimp appetizer, I do not remember the name on the menu. After that I highly recommend the braised birria elote risotto.
Ordered by phone. It was well worth it. Great portions, tasty ingredients and freshly cooked. It was more expensive but well worth it. The lobster enchiladas - loved the sauce and has chorizo when mixed well with the lobster. Vegetables fajitas - some many onions and bell peppers, i loved it. The green chili burrito - I'm not fan of smothered burritos, but it was so tasty and worth trying. The kids bean and rice bowl - it was flavored very well, but I'd try something else next time. Surprisingly the French fries were also tasty, prefect if there's a picky eater. Tres leches - so good, prefectly soaked. Yes, I'll be back to try something else.
Lots of options to customize I really feel everyone can find something.
You have to try this place if you haven't already. Awesome drinks and attentive staff but it's the food that won me over. I'm so happy I found this place. The Elote dip is bomb! They even came up with this crazy green chili au graten, that is out of this world.
I was on vacation in the area and someone recommended this spot to me since I was on a quest for mole. This place delivered and it was glorious!
This place was worth the wait (though I recommend a reservation). Staff was attentive and kind. The dining room has a unique ambiance, and we enjoyed the background live music. We ordered the pollo a la crema and the burger del momento and enjoyed both. We would definitely take friends to this special spot!
Exceptional food, fantastic service and everyone is so sweet and welcoming. I appreciate that they are predominately gluten free (I have celiac), and I can eat many things on the menu including desserts, that rarely happens. We honestly love coming here because we know it’s going to be a good time and we are always well taken care of. Cannot recommend this place enough!
We arrived without a reservation around 5:30pm on a Saturday. We had to wait for a table for 20 minutes but the staff were really friendly and accommodating. We ended up grabbing drinks at the bar while we waited. I ordered a Margarita which was portioned well, strong but not over powering. My husband ordered a smoked old fashioned and that was aesthetically cool but also tasted great. For dinner I ordered the Chefs Special, duck with mole, butternut squash risotto and plantains. It was honestly the best duck I ever had. The portion was large, the dish was cohesive, the added pickled red onions with the duck added the sweet and sour note to the dish. The duck was tender and fell apart upon cutting. It wasn't too greasy. The risotto had a subtle creamy butternut flavor. The plantains added a crunch. It was so yummy! My husband ordered the lobster enchiladas and the lobster was tender and the bell pepper brandy sauce was delicious! We ordered the kids bean and rice bowl with chicken for my son. He is a picky toddler and was shoveling it in his mouth. Overall the atmosphere and decor was stylish, the live music was nice and not too loud. We are definitely going back again.
Common questions about Guadalupe On Main
Guadalupe On Main is located at 1526 E Main St, Mesa, AZ 85203, United States, Mesa, AZ 85203, United States.
You can reach Guadalupe On Main by calling +1 480-272-7220.
Guadalupe On Main has a rating of 4.7 out of 5 based on 817 customer reviews.
Guadalupe On Main features the following accessibility: Wheelchair-accessible car park, Wheelchair-accessible entrance, Wheelchair-accessible seating, Wheelchair-accessible toilet.
Guadalupe On Main features the following from the business: Identifies as women-owned.
Guadalupe On Main features the following service options: On-site services, Takeaway, Dine-in, Delivery.
Guadalupe On Main features the following highlights: Fast service, Great beer selection, Great cocktails, Great dessert, Live music, Serves local specialty.
Guadalupe On Main features the following popular for: Lunch, Dinner, Solo dining.
Guadalupe On Main features the following offerings: Alcohol, Beer, Cocktails, Coffee, Comfort food, Happy-hour drinks, Healthy options, Small plates, Spirits, Vegan options, Vegetarian options, Wine.
Guadalupe On Main features the following dining options: Brunch, Lunch, Dinner, Dessert, Seating, Table service.
Guadalupe On Main features the following amenities: Bar on site, Restroom.
Guadalupe On Main features the following atmosphere: Casual, Cozy, Lively, Romantic, Trendy, Upmarket.
Guadalupe On Main features the following crowd: Family friendly, Groups, LGBTQ+ friendly, Tourists, Transgender safe space.
Guadalupe On Main features the following planning: Dinner reservations recommended, Accepts reservations.
Guadalupe On Main features the following payments: Credit cards, Debit cards, NFC mobile payments.
Guadalupe On Main features the following children: High chairs, Kids' menu.
Guadalupe On Main features the following parking: Free parking lot, Free street parking, Plenty of parking.
Business Features
We look forward to welcoming you. Make a reservation or stop by - walk-ins welcome!
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